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ENZYMEL products effectively help address inflammation of the gums and oral mucosa. They are the only products on the market designed for oral hygiene that contain proteolytic enzymes. These influence inflammation and support regeneration. ENZYMEL products were developed by the Czech family company Wald Pharmaceuticals as a result of over 30 years of research.

During the development of ENZYMEL products, patients are always our top priority. We particularly focus on patients with oral inflammation and their specific and genuine needs. Thus, they help with conditions such as gingivitis, periodontitis, aphthous ulcers, or mucositis. Our ENZYMEL products with proteolytic enzymes are easy to use and gentle. Satisfied patients return and use ENZYMEL products long-term – over 10 years, tens of thousands of people have done so. The composition of both pastes and gels is maximally gentle; no or very mild flavor does not irritate the gums. The patented blend of enzymes with chlorhexidine allows for a reduction in the amount of antiseptic and significantly limits its side effects.

ENZYMEL products contain a combination of proteolytic enzymes that optimize the inflammatory response and reduce the risk of chronic inflammation. They optimize healing processes by reducing swelling, enhancing mucosal immunity, and improving blood and lymph microcirculation. More information here.

The red line of products ENZYMEL Parodont red line (mucoadhesive gel, toothpaste, and dry gel in lozenges) is designed for daily and long-term oral care, including prevention. It is particularly beneficial for patients with acute inflammation of the oral mucosa and gums (gingivitis, periodontitis), post-surgery, after dental hygiene, during temporarily reduced immunity due to another illness, or for long-term care in cases of diabetes, post-surgery, radiotherapy in the head and neck area, or during pregnancy.

The red line of products ENZYMEL Parodont (mucoadhesive gel, toothpaste, lozenges) contains proteolytic enzymes that optimize healing processes by reducing swelling, enhancing mucosal immunity, and improving blood and lymph microcirculation.

The blue line of products ENZYMEL Intensive 35 (mucoadhesive gel, toothpaste) is intended for oral care in inflammatory conditions caused by or accompanied by bacterial infection, or where there is a risk of such infection (e.g., more serious postoperative conditions, chronic and recurrent inflammation, post-implantation care).

The blue line of products ENZYMEL Intensive 35 (mucoadhesive gel, toothpaste) contains a patented blend of proteolytic enzymes and the antiseptic chlorhexidine. They are suitable for intensive hygiene aimed at protecting against bacterial infection. The patented blend is effective yet gentle, without undesirable side effects. It does not stain teeth or irritate the tongue, which is a typical side effect of higher chlorhexidine concentrations in dental hygiene products. Thanks to the reduced concentration, but maintained efficacy, ENZYMEL Intensive 35 can be used for up to 8 weeks, leveraging the antimicrobial properties of the products.

Furthermore, proteolytic enzymes optimize healing processes by reducing swelling, enhancing mucosal immunity, and improving blood and lymph microcirculation.

Mucoadhesive means adhesive. ENZYMEL gels are the only mucoadhesive gels on the Czech market because they are completely flavorless. A mucoadhesive gel thus adheres to the oral mucosa and does not induce excessive salivation and subsequent washing away by saliva into the stomach.

Thanks to the combination of mucoadhesivity and neutral taste, the duration of active substance action is significantly extended.

Chlorhexidine is an antiseptic, meaning it inhibits the growth of microorganisms. Chlorhexidine has a broad-spectrum antiseptic effect (acting against bacteria, molds, viruses, and yeasts). In dentistry, it is used to prevent bacterial infection and inflammation.

Chlorhexidine alone is effective at concentrations of 0.12% and higher, but it has undesirable side effects. Taste disturbances, tooth discoloration, and tongue darkening often occur.

The synergistic action of chlorhexidine with proteolytic enzymes in the patented blend of ENZYMEL Intensive 35 products has made it possible to reduce the chlorhexidine concentration by up to 4 times (to 0.035%) while maintaining antimicrobial efficacy. As a result, ENZYMEL Intensive 35 does not have the undesirable side effects typical of chlorhexidine alone. Thus, ENZYMEL Intensive 35 can be used without problems for up to 2 months. More here.

Only a flavorless gel can act in the oral cavity for a sufficiently long time. Flavored gels cause saliva production and immediate flushing of the active substance into the stomach. ENZYMEL gels are the only truly mucoadhesive gels on the Czech market. Because they are completely flavorless and contain a mucoadhesive component, they adhere to the mucous membranes and act longer.

All excipients in ENZYMEL products are classified as SAFE by the U.S. Food and Drug Administration (FDA).

Gums are very sensitive, and every additional chemical substance unnecessarily burdens and weakens them. Many of the excipients used merely serve to make products taste and look better, but they do not have a positive effect on gums and teeth.

For all ENZYMEL products, we meticulously ensure the use of a minimal amount of excipients. We operate on the premise that irritated gums are far more sensitive to excessive flavor and excipients (such as alcohol). ENZYMEL products do not contain dyes or substances to enhance appearance (e.g., titanium dioxide), which can excessively irritate the gums. At the same time, we recognize that limiting excipients is the minimum we can contribute to a healthier environment.

Our goal is to create products with maximum efficacy that are simultaneously gentle on the gums. Sodium lauryl sulfate (SLS) is an industrial foaming agent, which is attributed, among other things, to contributing to the development of allergies. It is one of the excipients used for the sensation of foaming in the mouth. In laboratories, SLS is used for the denaturation (destruction) of proteins and enzymes.

ENZYMEL toothpastes have lower foaming than you might be used to with conventional toothpastes. However, higher foaming does not mean higher efficacy; it is merely a cosmetic effect that can create a ‘false sense’ of clean teeth.

Fluoride is used in oral hygiene products for enamel remineralization. ENZYMEL Parodont and ENZYMEL Intensive 35 toothpastes are produced with fluoride.

Gels ENZYMEL Parodont and ENZYMEL Intensive 35 do not contain fluorides and are suitable for patients with fluoride allergies.

Astringent substances, such as aluminum, tannin, tobacco smoke, and others, cause “temporary constriction of blood capillaries”, which leads to a false sense of reduced bleeding. This effect lasts approximately 12 hours. Unfortunately, by closing the blood capillaries, neither nutrients nor immune cells can penetrate the gums, and conversely, toxic metabolic and inflammatory byproducts cannot exit.

Gum bleeding is one of the manifestations of inflammation. We maintain that it is primarily necessary to address the cause of inflammation, not merely the symptoms.

Proteolytic enzymes in ENZYMEL products optimize conditions for ongoing inflammation and regeneration. Proteolytic enzymes improve blood circulation in the gums and mucous membranes, reduce swelling, and enhance mucosal immunity. Their benefit is long-term, unlike astringent substances, where the cosmetic effect appears quickly but fades after a few hours, while inflammation continues.

Gum bleeding is one of the manifestations of inflammation. Aluminum compounds can constrict blood vessels, so the gum does not bleed for a certain period. However, this only temporarily limits the symptoms of inflammation, not its cause.

Proteolytic enzymes in ENZYMEL products optimize conditions for ongoing inflammation and regeneration. Proteolytic enzymes improve blood circulation in the gums and mucous membranes, reduce swelling, and enhance mucosal immunity. Their benefit is long-term, unlike astringent substances like aluminum, where the cosmetic effect appears quickly but fades after a few hours, while inflammation continues.

The synergistic effect of the simultaneous use of proteolytic enzymes and chlorhexidine allows for a significant reduction in chlorhexidine concentration while maintaining its efficacy. Proteolytic enzymes disrupt the bonds in bacterial biofilm, thus enabling chlorhexidine to penetrate deeper layers of plaque and effectively kill bacteria that cause gum inflammation.

The combination with proteolytic enzymes allowed us to reduce the chlorhexidine concentration by up to 4 times in ENZYMEL Intensive 35 products while maintaining the same antimicrobial activity. This eliminated undesirable side effects such as tooth discoloration, salivary disorders, or tongue roughness, which typically accompany treatment with chlorhexidine products, and extended the safe period of its use.

Alcohol (often used for preparing plant extracts) contributes to gum dryness, which is why our products do not contain it. The development of ENZYMEL products took place in cooperation with numerous specialized workplaces, considering the needs of patients with inflammation or other oral cavity problems (dry socket, canker sores, gingivitis, periodontitis, periodontosis, mucositis – inflammation of the oral mucosa, for example, during radiation or cytostatic treatment, etc.).

For the same reason, toothpastes contain the lowest possible concentrations of aromatic substances (anethole, mint), so that, even while maintaining a mild menthol flavor, they are gentle even on very sensitive gums.

We developed both lines for targeted yet gentle care in inflammatory conditions. The red line products, ENZYMEL Parodont, can be used for daily and long-term care to prevent problems and for mild gum, teeth, and oral cavity issues. They are particularly suitable, for example, for incipient inflammations, after dental hygiene, when using orthodontic appliances, as part of oral cavity preparation before surgery, for postoperative and post-traumatic conditions, in diabetes, or during pregnancy.

The blue line, ENZYMEL Intensive 35, with antimicrobial effects, is intended for oral cavity care in inflammatory conditions caused or accompanied by bacterial, viral, or yeast infection, or where the risk of such infection exists, e.g., postoperative conditions, chronic and recurrent inflammations, post-implantation period, etc.

An important part of dental hygiene is deep cleaning (removal of calculus below the gumline). During this procedure, mild traumatization of soft tissues occurs. The patient may temporarily experience a feeling of gum swelling, or their gums may bleed even with gentle pressure (tooth brushing, chewing harder foods).

Until the tissue recovers from the trauma, it is more susceptible to bacterial colonization and thus to inflammation. The use of ENZYMEL products with proteolytic enzymes facilitates the healing of soft tissues and periodontal pockets after dental hygiene, and simultaneously prolongs the positive effect of dental hygiene.

Yes, the mucoadhesive gel ENZYMEL Parodont promotes healing and reduces the risk of complications after tooth extraction. For an uncomplicated extraction, it is advisable to start application approximately 12–24 hours after the procedure, when a coagulum, a blood clot covering the wound, has already formed.

Apply the gel between the gums and lips 2-3 times daily until healed. When transitioning to regular mechanical hygiene after extraction, we recommend using ENZYMEL Intensive 35 toothpaste for 1 month (1 package) to reduce the risk of infection, and then switching to ENZYMEL Parodont toothpaste.

It depends on the condition or ailment you are experiencing. Generally, the gel should be used at least 2-3 times daily. We recommend applying the gel at least 30 minutes after eating or a sweet drink (saliva production will cease, thereby increasing the gel’s effect).

Ideally, rinse your mouth with water before use and gently dry your gums (e.g., with a tissue). Apply a small amount of gel to the gums (using a cotton swab, a soft brush, or a clean finger) and spread it. In case of wide interdental spaces, you can press the gel directly between the teeth using a narrow applicator.

You can also use night guards. This significantly prolongs the effect of proteolytic enzymes and chlorhexidine on tooth enamel and surrounding soft tissues. For severe forms of inflammation, the guard can also be used during the day. When having it made, request a groove for gel application in the gum area, into which the gel is applied (similarly, guards with a groove for bleaching chemicals are made – however, the groove is located in the tooth area).

ENZYMEL products can be used for tissue preparation before implantation and also for better and uncomplicated healing after implantation. For successful implant integration, it is important that the oral cavity is in the best possible condition before implant placement. Your dentist or dental hygienist will recommend proper care, and ENZYMEL products can also effectively assist in the gum preparation phase for the planned procedure.

If antibiotics are necessary after implantation or other oral surgery, ENZYMEL products will not only support tissue healing but also enhance the effectiveness of antibiotics. The blue line products ENZYMEL Intensive 35 contain a unique blend of proteolytic enzymes with the antiseptic chlorhexidine, providing targeted antimicrobial action.

The oral cavity in diabetics is more susceptible to bacterial infection. In addition to an increased risk of gingivitis (and a more severe course thereof), diabetics also face other oral health problems, such as yeast infection (candidiasis) or dry mouth (xerostomia).

ENZYMEL products are suitable for effective daily oral hygiene, as proteolytic enzymes support mucosal immunity, help optimize the course of inflammation in the oral cavity, contribute to more effective interdental hygiene, help suppress bacterial adhesion to tooth enamel, and reduce bacterial plaque formation. Read more about diabetes and the effects of ENZYMEL products.

Radiotherapy in the head and neck region and chemotherapy carry an increased risk of oral mucositis and dry mouth (due to salivary gland damage). ENZYMEL products contain proteolytic enzymes that optimize the healing process, reduce potential swelling, support the effect of antibiotic treatment, and promote mucosal moisture and the maintenance of good mucosal immunity.

For inflammatory complications, we recommend using the blue line ENZYMEL Intensive 35, which contains a patented blend of proteolytic enzymes with chlorhexidine. Thanks to the enzyme content, we were able to significantly reduce the chlorhexidine dosage while maintaining its antimicrobial efficacy (details here).

During orthodontic treatment, thorough daily care of teeth and gums is essential, whether you wear removable, fixed, or invisible braces. Cleaning teeth with braces is more challenging due to increased plaque accumulation around orthodontic brackets or bands. Furthermore, local irritation of the gums, lips, or cheeks may occur; the problem can progress to a chronic stage, complicating oral hygiene due to the treatment of painful areas.

Dentures also require careful cleaning, and especially new dental prostheses can cause painful pressure sores.

ENZYMEL products offer effective assistance for chronic trauma and more demanding hygiene with braces or dentures. The proteolytic enzymes contained in ENZYMEL products reduce the ability of bacteria to adhere to the surface of gums and teeth, disrupt plaque, improve the condition of painful and chronically irritated areas, reduce swelling, and optimize the course of inflammatory reactions. They break down proteins that accumulate on braces and dentures and can form the basis of bacterial or yeast biofilm.

Smokers’ gums are often exposed to the risk of “hidden periodontitis,” which is only discovered when it becomes very difficult to combat. Substances contained in tobacco smoke have an astringent effect, constricting vascular capillaries in the gums, so smokers’ gums generally bleed less (similar to gums when using products with an astringent effect). This masks one of the most prominent signs of ongoing inflammation.

ENZYMEL products contribute to the overall improvement of mucosal immunity, which is weakened due to smoking. Other positive effects of proteolytic enzymes (optimization of healing conditions, reduction of bacterial adhesion, and dental plaque formation) also support the effectiveness of oral hygiene, to which smokers should pay increased attention.

The best way to restore the health of the mouth, gums, and teeth is to stop smoking. However, it is important to consider that many “hidden” problems may only become apparent after the astringent effect of toxic smoke subsides.